AIMS of the CPPR

  • To reformulate existing evidence-based prevention programs with structures and formats (intervention designs) that incorporate adaptive-sequential, brief, targeted, and modularized personalized strategies. These reformulated designs will be constructed in a way that preserves their original focus and content, but presents them in a more creative, flexible, and pragmatic fashion that increases their effectiveness, efficiency, accessibility and acceptability while reducing cost.
  • To formulate new and innovative preventive intervention designs/delivery systems based on (a) new approaches in client decision-making where clients choose from a menu of intervention options the one that is most appealing to them, and (b) new behavioral intervention technologies which capitalize on youth’s preference and use of technology, including mobile devices such as app-enabled smart phones and lifestyle trackers.
  • To identify from studies of moderation candidate tailoring variables that may be used to enrich personalized intervention designs via the construction of decision rules that assign individuals to specific intervention designs that optimize their outcomes.
    →Personal and contextual characteristics that embody risk and/or protective factors that influence response to various types of intensity of intervention. In the search for informative tailoring variables, the CPPR applies translational tactics to leverage discoveries in genetics, epigenetics neurobiology, environmental science, and family science to identify the mechanisms through which personalized preventive interventions effectively change developmental risk trajectories.
  • To assess the feasibility of implementing personalized intervention models in youth-serving community systems-of-care. Feasibility will include establishing that personalized intervention design is accessible, acceptable and culturally sensitive for various high risk populations and can be implemented with efficiency and fidelity by real-world implementers across various systems-of-care.
  • To conduct economic analysis to calculate the net benefit (benefits minus costs) and the cost effectiveness ratio associated with the personalized interventions. Estimating the cost-effect ratio will allow for the comparison of economic effectiveness across various personalized and standard interventions that target the same desired outcomes.

The CPPR was funded by a grant awarded by the National Institute of Mental Health: P20 MH085987